Marina Anastasiou, MSc – Woman in Pathology

Marina Anastasiou, MSc

Marina Anastasiou, MSc is a predoctoral fellow at the Pilar Alcaide lab at Tufts University Graduate School of Biomedical Studies. She received her Bachelor and Masters degrees in her home country of Greece before joining the Alcaide lab as a doctoral candidate. She studies innate sensing by the vascular endothelium as well as the innate sensing in the context of the leukocyte recruitment cascade. She is a recipient of the ASIP Trainee Travel Awards for EB2019 and EB2020.

Honors Include

  • Runner-up for the Hellenic Students Abroad Initiative (Thessaloniki Chapter) accompanied by paid attendance to a summer program in Vaccinology at the University of Antwerp Medical School
  • Entrepreneurship Award (Silver) for project titled: “Olfaction post-production” accompanied by tuition waiver for certification: “Innovation & Entrepreneurship”
  • Named Erasmus+ Scholar and selected for a research program at Boston University School of Medicine
  • Recipient of ASIP trainee travel award to present at EB2019
  • Recipient of ASIP trainee travel award to present at EB2020

Research

Her research in the Alcaide lab focuses on understanding the role of sialomucin CD43 in T cell immune responses and in activated T cell interactions with the vascular endothelium and trafficking to sites of inflammation. She combines flow chamber studies and real time videomicroscopy with several in vivo models of antigen dependent and antigen independent acute and chronic inflammation. Having acquired the necessary skills to study T cell interactions with endothelial cells, she also started a research project to study the role of the innate sensing molecule Stimulator of Interferon genes (STING) in non-hematopoietic cells, focusing on endothelial cells, critical in leukocyte trafficking and in wound healing.

Her training has been an exciting and decisive step towards achieving her long-term goal of becoming an independent cardiovascular immunologist, while contributing significantly to the novel understanding of endothelial STING in vascular injury, commonly present in millions of people suffering from cardiovascular disease.


Publications:

  1. Carrillo-Salinas FJ, Ngwenyama N, Anastasiou M, Kaur K, and Alcaide P. Heart Inflammation: Immune Cell Roles and Roads to the Heart. Am J Pathol 189: 1482-1494, 2019.
  2. Anastasiou M, Carrillo-Salinas FJ, Kaur K, Muendlein HI, Poltorak A, Alcaide P. Stimulator of Interferon Genes Deletion in Primary Heart Endothelial Cells Results in Decreased T Cell Transmigration. FASEB J. 33.1_supplement.374.5.
  3. Carrillo-Salinas FJ, Ngwenyama N, Anastasiou M, Kaur K, Aronovitz M, Alcaide P. Gut Bacteria Modulate T Cell Responses and Adverse Cardiac Remodeling in Pressure Overload Induced Heart Failure. FASEB J. 33.1_supplement.374.2.
  4. 2020 (pending): (as second author) Abstract Submission ID: R4396_Gut Dysbiosis Induced by Cardiac Pressure Overload Promotes T Cell Activation and Adverse Cardiac Remodeling Through Alterations in the Aryl Hydrocarbon Receptor Expression
  5. 2020 (pending): (as first author) Abstract Submission ID: R4103_ Stimulator of Interferon Genes (STING) Regulates Endothelial Healing and Reendothelialization Following Angioplasty-Mediated Vascular Injury