Magali Saint-Geniez , PhD – Women in Pathology

Magali Saint-Geniez , PhD
Harvard Medical School, Associate Professor of Ophthalmology
Schepens Eye Research Institute of Massachusetts Eye and Ear, Assistant Scientist

Dr. Magali Saint-Geniez earned her PhD from the University of Toulouse, France where she trained in vascular research at the ISERM laboratory. In 2002, she joined the Schepens Eye Research Institute at Mass. Eye and Ear to pursue her postdoctoral training in the laboratory of Dr. Patricia D’Amore. At that time, she identified the essential role of endogenous vascular endothelial growth factor (VEGF) retinal function. After opening her independent lab in 2009, she shifted her focus to investigating novel pathogenic mechanism of degenerative retinal diseases and developing new translational technologies for clinical application.

Scientific Biography:

Using a multidisciplinary approach integrating bioengineering, stem cell technology, and disease modelling, her group is investigating the underlying pathogenic roles of metabolic dysfunction and oxidative damage in photoreceptors and retinal pigment epithelium, and is evaluating the therapeutic benefits of novel metabolic regulators. Some of her achievements include the identification of PGC-1 as a critical regulator of RPE metabolism and response against oxidative damage, the characterization of novel heterotypic cellular interactions required for the homeostasis of the outer retina, and the development of new biomimetic scaffolds for effective RPE transplantation. By broadening the current understanding of the impact of metabolism on retinal homeostasis and highlighting the critical significance of metabolic dysfunction in common retinal pathologies her contributions were recognized by the American Society of Investigative Pathology (Cotran Early Career Investigator Award, 2016) and the Alcon Research Institute (Young Investigator Award, 2017).

ASIP involvement:

Dr. Saint-Geniez joined ASIP as a post-doctoral fellow over 10 years ago and has since actively participating in many yearly conferences at EB. As an academic scientist, Dr. Saint-Geniez is dedicated to growing the next generation of researchers through inspiring mentoring and education. She is particularly sensitive to the issues of gender equality and diversity in the academic environment, and actively participates in local and national programs facilitating the mentoring and professional development of women and minorities in science. To this end she has been an active member of the ASIP Committee for Career Development and Diversity since 2016. and have served on the Committee for Career Development and Diversity since 2016 and chaired the Career Development Sunday Workshop at EB2018. In May 2020, Dr. Saint-Geniez was elected as the new Chair of the ASIP Publication Committee where she will lead the current efforts, in close partnership with AJP leadership and the ASIP council, to foster the innovative perspectives brought by our members, refine and implement strategies for maximizing productivity and recognition, and develop new publication revenue pipelines.