A Hypothesized Role for Dysregulated Bradykinin Signaling in COVID-19 Respiratory Complications

ASIP member Dr. Joseph Roche (Wayne State University) recently published a paper in FASEB J. along with co-author Dr. Renuka Roche (Eastern Michigan University). Their paper hypothesizes a bradykinin [BK] model for COVID-19 complications and they suggest use of the FDA-approved BK blocker in the treatment of patients with COVID-19 respiratory disease. The abstract from the paper is given below and the final paper can be downloaded from FASEB J. using the link provided

Dr. Joseph A. Roche, BPT, Dip. Rehab. PT, PhD
Assistant Professor
Physical Therapy Program
Wayne State University
Detroit, MI

As of April 20, 2020, over time, the COVID-19 pandemic has resulted in 157,970 deaths out of 2,319,066 confirmed cases, at a Case Fatality Rate of ~6.8%. With the pandemic rapidly spreading, and health delivery systems being overwhelmed, it is imperative that safe and effective pharmacotherapeutic strategies are rapidly explored to improve survival. In this paper, we use established and emerging evidence to propose a testable hypothesis that, a vicious positive feedback loop of des-Arg(9)- bradykinin- and bradykinin-mediated inflammation → injury → inflammation, likely precipitates life threatening respiratory complications in COVID-19. Through our hypothesis, we make the prediction that the FDA-approved molecule might be able to interrupt this feedback loop and, thereby, improve the clinical outcomes. This hypothesis could lead to basic, translational, and clinical studies aimed at reducing COVID-19 morbidity and mortality.