Sharing large-scale patient data to understand COVID-19 severity

HCS and ASIP member Dr. Alejandro Adam recently co-authored two preprints with collaborators at Albany Medical College, the University of Wisconsin, Madison and the Morgridge Institute for Research. This research, led by Drs. Ariel Jaitovich (Albany Med) and Joshua Coon (UW-Madison), shows how multiplexed measurements, large-scale multi-omics analysis and artificial intelligence can shed light into why some patients quickly recover, while others have a much worse prognosis. The data shows high levels of CCL19, but low levels of PDGF-AA, dysregulation of platelet function, blood coagulation, acute phase response, and endotheliopathy in patients with worse prognosis, providing insight into novel potential therapeutic interventions. All cytokine profiling, metabolomics, lipidomics, proteomics, transcriptomics from a prospective cohort of 120 patients were made freely available to the whole scientific community.

More info:

https://www.medrxiv.org/content/10.1101/2020.05.21.20051300v2
https://www.medrxiv.org/content/10.1101/2020.07.17.20156513v1
https://covid-omics.app


  • ASIP Member Dr. James Musser featured for COVID-19 Research

    James Musser, MD, spoke with The New York Times about how COVID-19’s genetic code plays a vital role in controlling the virus.

    Since last March, a team of researchers led by Dr. James Musser, chair of the department of pathology and genomic medicine at Houston Methodist Hospital, have been sequencing the viral genomes drawn from patients — 20,000 genomes so far. This new study has found that every coronavirus variant of concern to researchers around the world has been circulating in Houston at a low level for at least six to eight weeks. Houston is the first U.S. city to find all of the variants, including those recently reported in California and New York and the ones found in Brazil, Britain and South Africa.

  • #PISA2020 Day 5
    Program Yesterday was another full day of science, mentoring, and networking at PISA 2020. With Day 4 of the meeting in the books, we find ourselves at Day 5 – the final day of PISA 2020. TODAY at PISA 2020, we begin with Trainee Advising Sessions at 8:00 AM and 9:00 AM on the topics […]
  • Pathologists Fighting COVID-19 – Sally Davis
    K-State Assistant Professor of Experimental Pathology, Dr. A. Sally Davis, an ASIP member and HCS Councilor, will lead USDA-National Institute of Food and Agriculture Rapid Response project “Translating SARS-CoV-2 Research Into Practical Solutions For The Meat And Poultry Processing Industry” to find scientific solutions to protect meat and poultry plant workers and their surrounding communities […]