HCS and ASIP member Dr. Alejandro Adam recently co-authored two preprints with collaborators at Albany Medical College, the University of Wisconsin, Madison and the Morgridge Institute for Research. This research, led by Drs. Ariel Jaitovich (Albany Med) and Joshua Coon (UW-Madison), shows how multiplexed measurements, large-scale multi-omics analysis and artificial intelligence can shed light into why some patients quickly recover, while others have a much worse prognosis. The data shows high levels of CCL19, but low levels of PDGF-AA, dysregulation of platelet function, blood coagulation, acute phase response, and endotheliopathy in patients with worse prognosis, providing insight into novel potential therapeutic interventions. All cytokine profiling, metabolomics, lipidomics, proteomics, transcriptomics from a prospective cohort of 120 patients were made freely available to the whole scientific community.
- Mouse Models Reveal Role of T-Cytotoxic and T-Reg Cells in Immune Response to Influenza: Implications for Vaccine DesignArticle of Interest: Abstract: Immunopathologic examination of the lungs of mouse models of experimental influenza virus infection provides new insights into the immune response in this disease. First, there is rapidly developing perivascular and peribronchial infiltration of the lung with T-cells. This is followed by invasion of T-cells into the bronchiolar epithelium, and separation of […]
- Grab a shovel: How the over 65K published articles on COVID can teach us to be better scientists.On July 23rd 2020 there were a reported total 66,883 peer reviewed open access articles on the novel coronavirus COVID-19. That does not include the 19,420 preprints that have also been reported. So let’s say we are at over 85K publications about COVID-19 in 2020. I don’t know about you, but that sounds out of […]
- Pathologists Fighting COVID-19 – LSU Health New OrleansA series of autopsies conducted by the team of ASIP member, Dr. Richard Vander Heide, revealed surprising cardiac changes in COVID-19 patients. He recently was an invited speaker for the ASIP COVID-19 Webinar on the topic of Autopsy Insights into the Pathogenesis of COVID-19, where he had proposed the mechanism that the cardiac manifestations in […]