Dr. Anny-Claude Luissint

Dr Luissint is a junior faculty member in the Department of Pathology at the University of Michigan (United States). She completed her PhD in cell biology from Paris Descartes University (Paris, France) studying the contribution of a Junctional Adhesion Molecule (JAM) family member termed JAM-L in regulating leukocyte transendothelial migration. Dr Luissint joined the labs of Dr Charles Parkos and Dr Asma Nusrat as a postdoctoral research fellow at Emory University, then moved to the University of Michigan and, she was appointed as a Research Investigator in March 2019.

Dr Luissint’s overall interest is in understanding how intercellular adhesion proteins regulate the intestinal epithelial barrier function, mucosal repair and the immune response. She is studying the causal relationship between a leaky gut, inflammatory bowel disease (IBD) and colorectal tumorigenesis. Dr Luissint’s work has been published in outstanding peer-reviewed journals such as Nature communications, J Cell Biol, JCI insight, Mucosal Immunology, Gastroenterology and Mol Biol Cell. Her work has been cited over 1,000 times and her major contributions include demonstration of roles for the tight junction protein JAM-A, desmosomal cadherin Desmocollin-2 and CD47 in regulating barrier function, inflammation and mucosal wound healing, respectively. During this time, she was instrumental in helping develop an original in vivo murine model that utilizes a vascularized proximal colonic segment (pcLoop model) to enable quantitative studies of intestinal permeability and leukocyte trafficking across the colonic epithelium in response to chemoattractants. Dr Luissint is a reviewer for several scientific journals and an Associate faculty member of the Faculty opinions (Former F1000 Faculty) where she selects, evaluates and recommends articles to be considered of major interest to the international scientific community.

Dr. Luissint has been a member of the American Society of Investigative Pathology (ASIP) since 2014. She has received multiple awards including a ASIP Trainee Travel Award (San Diego, 2014), the ASIP Experimental Pathologist-in-training merit Award (Boston, 2015) and the Muller Trainee Travel Award for Excellence in Inflammation Research (Chicago, 2017). Dr Luissint was selected as an ASIP social ambassador for #ASIP2021.

Dr Luissint supports strategies to increase representation of women and diversity in Science. She enjoys extending her passion for research to younger scientists and is actively involved in training and mentoring graduate students, technicians and postdoctoral fellows.