Human diseases are exceptionally complex. Consider various forms of cancer, heart disease, diabetes, atherosclerosis, diseases of immunity, genetic diseases, infectious diseases, and many others. The causes of these disease processes are equally complex and almost always multifactorial, with contributions from the host/patient (related to genetics or physiology), various exposures to disease agents, factors from the environment, and many more. The patients themselves are complex and so the presentation, consequences, and severity of disease have a tendency to vary tremendously among an affected cohort. Despite recognition of these complexities associated with human disease, researchers have historically taken reductionists approaches to their study. Hence, our knowledge of many diseases reflect the combination of results (and inferences) from ex vivo approaches, in vitro cell culture, model systems, and examination of limited numbers of molecular mediators of disease. It has been recognized for many years that the complete understanding of any disease process will require the ability to examine the condition in the context of the patient, without elimination of the complexities of the in vivo condition. Welcome to the world of systems biology and network science!
Theme Issues DCIS Theme Issue Pancreatic Cancer Theme issue AJP Editor's Choice CD55 Is Essential for CD103+ Dendritic Cell Tolerogenic Responses that Protect against Autoimmunity CCN3/Nephroblastoma Overexpressed Is a Functional Mediator of Prostate Cancer Bone Metastasis That Is Associated with Poor Patient Prognosis Review Articles CD55 Is Essential for CD103+ Dendritic Cell Tolerogenic Responses that Protect against [...]
Journal of Molecular Diagnostics Editor-in-Chief: Barbara A. Zehnbauer, PhD, Adjunct Professor in Dept of Pathology at Emory University School of Medicine, Atlanta, GA Submit Today! Current issue: Open Access: Automated Clinical Exome Reanalysis Reveals Novel Diagnoses (https://jmd.amjpathol.org/article/S1525-1578(18)30062-X/fulltext) A Rigorous Interlaboratory Examination of the Need to Confirm Next-Generation Sequencing–Detected Variants with an Orthogonal Method in Clinical [...]
American Journal of Pathology Current Issue Network Medicine – Integrating the Future of Pathology ResearchPathogen Colonization Resistance in the Gut and Its Manipulation for Improved Health Review based upon 2019 Rous-Whipple Award Lecture Gabriel Nuñez Heart Inflammation - Immune Cell Roles and Roads to the Heart Review based upon 2018 ASIP Cotran Early Career Investigator [...]
Starting in January 2019, The American Journal of Pathology will be encouraging foundational studies relating to diseases that incorporate deep learning and artificial intelligence. Pathology research is increasingly relying on machine learning in the generation and analysis of large datasets and the AJP is dedicated to playing an enabling role in this evolution, as a [...]